2,5 dioxovalerate dehydrogenase

In enzymology, a 2,5-dioxovalerate dehydrogenase (EC 1.2.1.26) is an enzyme that catalyzes the chemical reaction

2,5-dioxopentanoate + NADP⁺ + H₂O ⇌ 2-oxoglutarate + NADPH + 2 H⁺

The 3 substrates of this enzyme are 2,5-dioxopentanoate, NADP⁺, and H₂O, whereas its 3 products are 2-oxoglutarate, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is 2,5-dioxopentanoate:NADP+ 5-oxidoreductase. Other names in common use include 2-oxoglutarate semialdehyde dehydrogenase, and alpha-ketoglutaric semialdehyde dehydrogenase. This enzyme participates in ascorbate and aldarate metabolism.