| Oral, Insufflation|
| CA: Schedule I
UK: Class A|
Oral administration, Insufflation
2,5-Dimethoxy-4-fluoroamphetamine (DOF) is a psychedelic drug of the phenethylamine and amphetamine classes. Alexander Shulgin briefly describes DOF in his book PiHKAL:
Animal studies that have compared DOF to the highly potent DOI and DOB imply that the human activity will be some four to six times less than these two heavier halide analogues. As of the present time, no human trials of DOF have been made.
DOF showed some stimulating effects but no psychedelic activity at 3x6 mg (spaced by 1h, each) in humans. Trachsel further suspected that the molar refraction of the important 4-substituent in DOF and 2C-F may be too low to activate the 5-HT2A receptor sufficiently. DOF rather resembles the 4-unsubstituted 2,5-dimethoxyamphetamine than DOC, DOB or DOI.