1999 US Open – Women's Doubles

The 1999 US Open – Women's Doubles was the women's doubles event of the hundred-and-ninth edition of the US Open, the fourth and last Grand Slam of the year, and the most prestigious tournament in the Americas. Martina Hingis and Jana Novotná were the defending champions, but Hingis did not compete this year and Novotná teamed up with Natasha Zvereva. Novotná and Zvereva were eliminated in the third round by Liezel Horn and Kimberly Po.

Serena Williams and Venus Williams won the title, defeating Chanda Rubin and Sandrine Testud in the final, 4–6, 6–1, 6–4. This was the second doubles Grand Slam for the Williams sisters, and their second step towards completing a Doubles Career Golden Slam.