1999 US Open – Women's Singles

The 1999 US Open – Women's Singles was the women's singles event of the hundred-and-ninth edition of the US Open, the fourth and last Grand Slam of the year, and the most prestigious tournament in the Americas. Lindsay Davenport was the defending champion, but she was defeated in the semifinals by Serena Williams. Williams then won in the final, defeating World No. 1 Martina Hingis. This was Williams' first Grand Slam title, and she became the first African American woman to win a Grand Slam in the Open Era. She won five more titles in 2002, 2008, 2012, 2013 and 2014.

This tournament was also the Grand Slam debut of future Top 3 player and Grand Slam champion Anastasia Myskina.