22 February – Minister Jean Wolter dies, and is replaced by Jean Spautz.
19 April – Representing Luxembourg, Sophie & Magaly finish ninth in the Eurovision Song Contest 1980 with the song Papa Pingouin.
1 May – In football, Luxembourg beats Thailand 1-0: Luxembourg's first international victory since 1973.
9 May – The Luxembourgian national football team beats South Korea 3-2. This was Luxembourg's last international victory until 1995.
8 June – The Netherlands' Bert Oosterbosch wins the 1980 Tour de Luxembourg.
1 July – Footballer Robby Langers transfers from Union Luxembourg to German club Borussia Mönchengladbach.
21 November – Gaston Thorn is named as President of the European Commission.
22 November – Gaston Thorn steps down as Deputy Prime Minister and Minister for Foreign Affairs of Luxembourg and is succeeded by Colette Flesch. Camille Polfer replaces Flesch as Mayor of Luxembourg City.
15 April – Fränk Schleck, cyclist
19 February – Philippe Schneider, film director
22 February – Jean Wolter, politician
27 June – Marcel Fischbach, politician
12 July – Arsène Mersch, cyclist
23 October – Auguste Trémont, artist
1980 in Luxembourg Wikipedia (Text) CC BY-SA