1921 Tulsa Orange and Black football team

The 1921 Tulsa Orange and Black football team represented the University of Tulsa during the 1921 college football season. In their third year under head coach Francis Schmidt, the Orange and Black compiled a 6–3 record and outscored their opponents by a combined total of 257 to 95. The team won its first two games by scores of 92-0 over East Central and 75-13 over the Chilocco Indian Agricultural School. Head coach Francis Schmidt was later inducted into the College Football Hall of Fame.