The 1880 Open Championship was the 20th Open Championship, held 9 April at Musselburgh Links, Musselburgh, East Lothian, Scotland. Bob Ferguson won the Championship, by five strokes from runner-up Peter Paxton.
A number of players were absent because of the short notice given for the competition. Jamie Anderson, winner of the previous three Open Championships was amongst those that were missing. Good weather brought out a large number of spectators. The Championship was played over four rounds of the nine-hole Musselburgh course.
Andrew Kirkaldy scored a hole-in-one at the 8th hole in his second round and almost repeated the feat in his third round.
After three rounds Bob Ferguson was tied for the lead with Peter Paxton with Ned Cosgrove only a shot behind. In the final round Ferguson scored 39 to Paxton's and Cosgrove's 44s to win by five strokes.