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The 1859 Perugia uprising occurred on 20 June 1859, in Perugia, central Italy. The inhabitants rebelled against the temporal authority of the Pope (under the Papal States) and established a provisional government, but the insurrection was bloodily quashed by Pius IX's troops.
When Perugia later became free of papal control, due to Italian unification, King Victor Emmanuel II of Italy sent some of his troops to protect the retreating Swiss guards from the vengeful citizens.
References
1859 Perugia uprising Wikipedia(Text) CC BY-SA