16S rRNA (adenine1408 N1) methyltransferase

16S rRNA (adenine¹⁴⁰⁸-N¹)-methyltransferase (EC 2.1.1.180, kanamycin-apramycin resistance methylase, 16S rRNA:m1A1408 methyltransferase, KamB, NpmA, 16S rRNA m1A1408 methyltransferase) is an enzyme with systematic name S-adenosyl-L-methionine:16S rRNA (adenine¹⁴⁰⁸-N¹)-methyltransferase. This enzyme catalyses the following chemical reaction

S-adenosyl-L-methionine + adenine¹⁴⁰⁸ in 16S rRNA ⇌ S-adenosyl-L-homocysteine + N¹-methyladenine¹⁴⁰⁸ in 16S rRNA

The enzyme provides a panaminoglycoside resistance through interference with the binding of aminoglycosides.