16 alpha hydroxysteroid dehydrogenase

In enzymology, a 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) is an enzyme that catalyzes the chemical reaction

The 3 substrates of this enzyme are 16alpha-hydroxysteroid, NAD⁺, and NADP⁺, whereas its 4 products are 16-oxosteroid, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is 16alpha-hydroxysteroid:NAD(P)⁺ 16-oxidoreductase. This enzyme is also called 16alpha-hydroxy steroid dehydrogenase.