1452 - Leon Battista Alberti completes writing De Re Aedificatoria
1450 - Reconstruction of Sforza Castle in Milan as a palace begun
1451–1457 - Villa Medici in Fiesole, Tuscany, designed by Michelozzo or Leon Battista Alberti, built
c.1451 - Palazzo Rucellai in Florence, probably designed by Leon Battista Alberti and executed, at least in part, by Bernardo Rossellino, substantially completed
1452 - Hospices de Beaune in France, probably designed by Jacques Wiscrère, opened
1456 - Ospedale Maggiore in Milan begun by Filarete
1457 - Edo Castle in Japan first fortified by Ōta Dōkan
1458 - Pitti Palace in Florence begun by Bartolommeo Ammanati and perhaps Brunelleschi
Approximate date? - Palazzo Pisani Moretta on the Grand Canal (Venice) built
1450: Bartolomeo Montagna, Italian painter and architect (died 1523)
1452: April 15 - Leonardo da Vinci, Italian polymath (died 1519)
c.1456: Bramantino, born Bartolomeo Suardi, Milanese painter and architect (died c.1530)
1450s in architecture Wikipedia (Text) CC BY-SA