Girish Mahajan

14 Phenylpropoxymetopon

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PubChem CID  10238204
Formula  C27H31NO4
Molar mass  433.54 g/mol
ChemSpider  8413692
3D model (Jmol)  Interactive image
14-Phenylpropoxymetopon
Synonyms  14-Phenylpropoxymetopon, PPOM

14-Phenylpropoxymetopon (PPOM) is an opiate analogue that is a derivative of metopon which has been substituted with a γ-phenylpropoxy group at the 14-position. It is a highly potent analgesic drug several thousand times stronger than morphine, with a similar in vivo potency to etorphine. The 14-phenylpropoxy substitution appears to confer potent μ-opioid agonist activity, even when combined with substitutions such as N-cyclopropyl or N-allyl, which normally result in μ-opioid antagonist compounds.

It has never been used in humans, but would be expected to produce effects similar to those of other potent opioid agonists, including strong analgesia, sedation, euphoria, constipation, itching and respiratory depression which could be harmful or fatal. Tolerance and dependence would be expected to develop rapidly based on the potency of the drug, as it is of a similar strength to the potent fentanyl analogues and so would most likely cause pronounced tachyphylaxis following repeated dosing.

References

14-Phenylpropoxymetopon Wikipedia


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