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14 Methoxymetopon

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Synonyms  14-Methoxymetopon
PubChem CID  5486940
ChEMBL  CHEMBL326684
Molar mass  329.39 g/mol
CAS Number  131575-03-6
ChemSpider  4589140
Formula  C19H23NO4
14-Methoxymetopon

14-Methoxymetopon is an opiate analogue developed by a team led by Professor Helmut Schmidhammer at the University of Insbruck in the mid 1990s. It is a derivative of metopon in which a methoxy group has been inserted at the 14-position. It is a highly potent analgesic drug that is around 500x stronger than morphine when administered systemically; however, when given spinally or supraspinally, it exhibits analgesic activity up to a million fold greater than morphine. It binds strongly to the μ-opioid receptor and activates it to a greater extent than most similar opioid drugs. This produces an unusual pharmacological profile, and although 14-methoxymetopon acts as a potent μ-opioid full agonist in regard to some effects such as analgesia, a ceiling effect is seen on other effects such as constipation and respiratory depression which is believed to involve interaction with the κ-opioid receptor

References

14-Methoxymetopon Wikipedia


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