|EC number 184.108.40.206|
BRENDA BRENDA entry
KEGG KEGG entry
|IntEnz IntEnz view|
ExPASy NiceZyme view
In enzymology, a 1-phosphatidylinositol-5-phosphate 4-kinase (EC 220.127.116.11) is an enzyme that catalyzes the chemical reactionATP + 1-phosphatidyl-1D-myo-inositol 5-phosphate
Thus, the two substrates of this enzyme are ATP and 1-phosphatidyl-1D-myo-inositol 5-phosphate, whereas its two products are ADP and 1-phosphatidyl-1D-myo-inositol 4,5-bisphosphate.
This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing groups (phosphotransferases) with an alcohol group as acceptor. The systematic name of this enzyme class is ATP:1-phosphatidyl-1D-myo-inositol-5-phosphate 4-phosphotransferase. This enzyme is also called type II PIP kinase. This enzyme participates in 3 metabolic pathways: inositol phosphate metabolism, phosphatidylinositol signaling system, and regulation of actin cytoskeleton.