Ōtsuka (大塚, lit. "large mound") is a Japanese surname. Alternative transliterations include Otsuka and Ohtsuka. Notable people with the surname include:
Ai Otsuka (born 1982) Japanese pop singer from the Kansai region
Akinori Otsuka (born 1972) Japanese baseball player
Akio Ōtsuka (born 1959) Japanese voice actor, son of Chikao Ohtsuka
Chihiro Otsuka (born 1986) Japanese actress
Chikao Ōtsuka (1929-2015) Japanese voice actor, father of Akio Ohtsuka
Hironori Ōtsuka (1892–1982) the creator and first Grand Master of the Japanese karate style Wado-ryu
Hōchū Ōtsuka (born 1954) Japanese voice actor
James Otsuka (1921–1984) famous war tax resister
Julie Otsuka (born 1962) Japanese American author
Michael Otsuka (born 1964) London-based academian
Motoyuki "Morrie" Ōtsuka (born 1964) Japanese singer-songwriter
Tadashi Ohtsuka (born 1978) Japanese badminton player
Takeo Otsuka (born 1966) Japanese professional wrestler also known as Men's Teioh or Terry Boy
Yasuo Ōtsuka (born 1931) former animator who worked with Toei Animation
