(hydroxymethylglutaryl CoA reductase (NADPH)) phosphatase

In enzymology, a [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphatase (EC 3.1.3.47) is an enzyme that catalyzes the chemical reaction

[hydroxymethylglutaryl-CoA reductase (NADPH)] phosphate + H₂O ⇌ [hydroxymethylglutaryl-CoA reductase (NADPH)] + phosphate

Thus, the two substrates of this enzyme are hydroxymethylglutaryl-CoA reductase (NADPH) phosphate and H₂O, whereas its two products are hydroxymethylglutaryl-CoA reductase (NADPH) and phosphate.

This enzyme belongs to the family of hydrolases, specifically those acting on phosphoric monoester bonds. The systematic name of this enzyme class is [hydroxymethylglutaryl-CoA reductase (NADPH)]-phosphate phosphohydrolase. This enzyme is also called reductase phosphatase.