Kalpana Kalpana (Editor)

(glutamate—ammonia ligase) adenylyltransferase

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EC number  2.7.7.42
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  9077-66-1
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a [glutamate—ammonia-ligase] adenylyltransferase (EC 2.7.7.42) is an enzyme that catalyzes the chemical reaction

ATP + [L-glutamate:ammonia ligase (ADP-forming)] diphosphate + adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]

Thus, the two substrates of this enzyme are ATP and L-glutamate:ammonia ligase (ADP-forming), whereas its two products are diphosphate and [[adenylyl-[L-glutamate:ammonia ligase (ADP-forming)]]].

This enzyme belongs to the family of transferases, specifically those transferring phosphorus-containing nucleotide groups (nucleotidyltransferases). The systematic name of this enzyme class is ATP:[L-glutamate:ammonia ligase (ADP-forming)] adenylyltransferase. Other names in common use include glutamine-synthetase adenylyltransferase, ATP:glutamine synthetase adenylyltransferase, and adenosine triphosphate:glutamine synthetase adenylyltransferase.

Structural studies

As of late 2007, only one structure has been solved for this class of enzymes, with the PDB accession code 1V4A.

References

(glutamate—ammonia-ligase) adenylyltransferase Wikipedia


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