Samiksha Jaiswal (Editor)

(S) usnate reductase

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EC number
  
1.1.1.199

IntEnz
  
IntEnz view

ExPASy
  
NiceZyme view

CAS number
  
77237-99-1

BRENDA
  
BRENDA entry

KEGG
  
KEGG entry

In enzymology, a (S)-usnate reductase (EC 1.1.1.199) is an enzyme that catalyzes the chemical reaction

(6R)-2-acetyl-6-(3-acetyl-2,4,6-trihydroxy-5-methylphenyl)-3-hydroxy-6- methyl-2,4-cyclohexadien-1-one + NAD+ (S)-usnic acid + NADH + H+

In the reverse direction, (S)-usnate is reduced by NADH with cleavage of the ether bond to form a 7-hydroxy group.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is reduced-(S)-usnate:NAD+ oxidoreductase (ether-bond-forming). This enzyme is also called L-usnic acid dehydrogenase.

References

(S)-usnate reductase Wikipedia