Neha Patil (Editor)

(S) 2 methylmalate dehydratase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  9027-94-5
KEGG  KEGG entry

In enzymology, a (S)-2-methylmalate dehydratase (EC is an enzyme that catalyzes the chemical reaction

(S)-2-methylmalate 2-methylfumarate + H2O

Hence, this enzyme has one substrate, (S)-2-methylmalate, and two products, 2-methylfumarate and H2O.

This enzyme belongs to the family of lyases, specifically the hydro-lyases, which cleave carbon-oxygen bonds. The systematic name of this enzyme class is (S)-2-methylmalate hydro-lyase (2-methylfumarate-forming). Other names in common use include mesaconate hydratase, (+)-citramalate hydro-lyase, L-citramalate hydrolase, citramalate dehydratase, (+)-citramalic hydro-lyase, mesaconate mesaconase, mesaconase, and (S)-2-methylmalate hydro-lyase. This enzyme participates in c5-branched dibasic acid metabolism. In addition, the family of lyases which is also a enzyme catalyzes the breaking the elimination reaction of the variety of amounts of chemical bonds from hydrolysis (a substitution reaction ) and oxidation, which forms a new double bond or a new ring structure.


(S)-2-methylmalate dehydratase Wikipedia