Neha Patil (Editor)

(Ribulose bisphosphate carboxylase) lysine N methyltransferase

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EC number  2.1.1.127
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  139171-98-5
BRENDA  BRENDA entry
KEGG  KEGG entry

In enzymology, a [ribulose-bisphosphate carboxylase]-lysine N-methyltransferase (EC 2.1.1.127) is an enzyme that catalyzes the chemical reaction

S-adenosyl-L-methionine + [ribulose-1,5-bisphosphate carboxylase]-lysine S-adenosyl-L-homocysteine + [ribulose-1,5-bisphosphate carboxylase]-N6-methyl-L-lysine

Thus, the two substrates of this enzyme are S-adenosyl methionine and ribulose-1,5-bisphosphate carboxylase-lysine, whereas its two products are S-adenosylhomocysteine and ribulose-1,5-bisphosphate carboxylase-N6-methyl-L-lysine.

This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase (dimerizing)]-lysine N6-methyltransferase. Other names in common use include rubisco methyltransferase, ribulose-bisphosphate-carboxylase/oxygenase N-methyltransferase, ribulose-1,5-bisphosphate carboxylase/oxygenase large subunit, epsilonN-methyltransferase, S-adenosyl-L-methionine:[3-phospho-D-glycerate-carboxy-lyase, and (dimerizing)]-lysine 6-N-methyltransferase.

Structural studies

As of late 2007, 7 structures have been solved for this class of enzymes, with PDB accession codes 1MLV, 1OZV, 1P0Y, 2H21, 2H23, 2H2E, and 2H2J.

References

(Ribulose-bisphosphate carboxylase)-lysine N-methyltransferase Wikipedia


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