In enzymology, a (RS)-norcoclaurine 6-O-methyltransferase (EC 188.8.131.52) is an enzyme that catalyzes the chemical reactionS-adenosyl-L-methionine + (RS)-norcoclaurine
Thus, the two substrates of this enzyme are S-adenosyl methionine and (R,S)-norcoclaurine, whereas its two products are S-adenosylhomocysteine and (R,S)-coclaurine.
This enzyme belongs to the family of transferases, specifically those transferring one-carbon group methyltransferases. The systematic name of this enzyme class is S-adenosyl-L-methionine:(RS)-norcoclaurine 6-O-methyltransferase. This enzyme participates in alkaloid biosynthesis i.