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(R) p Isothiocyanatobenzoylecgonine methyl ester

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(R)-p-Isothiocyanatobenzoylecgonine methyl ester

(R)-p-Isothiocyanatobenzoylecgonine methyl ester (p-ISOCOC) is a cocaine analogue and irreversible (covalent) binding inhibitor of the cocaine receptor, as well as irreversible blocker of dopamine uptake by DAT (the latter being unlike its C3 homologue m-Isococ). p-Isococ also blocks the high-affinity cocaine site in preference to the low-affinity site.

References

(R)-p-Isothiocyanatobenzoylecgonine methyl ester Wikipedia


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