Girish Mahajan (Editor)

(R) dehydropantoate dehydrogenase

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EC number
IntEnz  IntEnz view
ExPASy  NiceZyme view
CAS number  37250-96-7
KEGG  KEGG entry

In enzymology, a (R)-dehydropantoate dehydrogenase (EC is an enzyme that catalyzes the chemical reaction

(R)-4-dehydropantoate + NAD+ + H2O (R)-3,3-dimethylmalate + NADH + 2 H+

The 3 substrates of this enzyme are (R)-4-dehydropantoate, NAD+, and H2O, whereas its 3 products are (R)-3,3-dimethylmalate, NADH, and H+.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the aldehyde or oxo group of donor with NAD+ or NADP+ as acceptor. The systematic name of this enzyme class is (R)-4-dehydropantoate:NAD+ 4-oxidoreductase. Other names in common use include D-aldopantoate dehydrogenase, D-2-hydroxy-3,3-dimethyl-3-formylpropionate:diphosphopyridine, and nucleotide (DPN+) oxidoreductase. This enzyme participates in pantothenate and coa biosynthesis.


(R)-dehydropantoate dehydrogenase Wikipedia