(R) 4 hydroxyphenyllactate dehydrogenase

In enzymology, a (R)-4-hydroxyphenyllactate dehydrogenase (EC 1.1.1.222) is an enzyme that catalyzes the chemical reaction

(R)-3-(4-hydroxyphenyl)lactate + NAD(P)+ ⇌ 3-(4-hydroxyphenyl)pyruvate + NAD(P)H + H⁺

The 3 substrates of this enzyme are (R)-3-(4-hydroxyphenyl)lactate, NAD⁺, and NADP⁺, whereas its 4 products are 3-(4-hydroxyphenyl)pyruvate, NADH, NADPH, and H⁺.

This enzyme belongs to the family of oxidoreductases, specifically those acting on the CH-OH group of donor with NAD⁺ or NADP⁺ as acceptor. The systematic name of this enzyme class is (R)-3-(4-hydroxyphenyl)lactate:NAD(P)⁺ 2-oxidoreductase. Other names in common use include (R)-aromatic lactate dehydrogenase, and D-hydrogenase, D-aryllactate. This enzyme participates in tyrosine and phenylalanine catabolism.