Kalpana Kalpana (Editor)

(KDO)2 lipid IVA (2 8) 3 deoxy D manno octulosonic acid transferase

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EC number  2.4.99.14
BRENDA  BRENDA entry
KEGG  KEGG entry
IntEnz  IntEnz view
ExPASy  NiceZyme view
MetaCyc  metabolic pathway

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase (EC 2.4.99.14, KDO transferase, waaA (gene), kdtA (gene), 3-deoxy-D-manno-oct-2-ulosonic acid transferase, 3-deoxy-manno-octulosonic acid transferase) is an enzyme with systematic name CMP-3-deoxy-D-manno-oct-2-ulosonate:(KDO)2-lipid IVA 3-deoxy-D-manno-oct-2-ulosonate transferase ((2->8) glycosidic bond-forming). This enzyme catalyses the following chemical reaction

alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP-alpha-Kdo alpha-Kdo-(2->8)-alpha-Kdo-(2->4)-alpha-Kdo-(2->6)-lipid IVA + CMP

The enzymes from Chlamydia transfer three or more 3-deoxy-D-manno-oct-2-ulosonate residues and generate genus-specific epitopes.

References

(KDO)2-lipid IVA (2-8) 3-deoxy-D-manno-octulosonic acid transferase Wikipedia