( ) alpha cuprenene synthase

(-)-alpha-cuprenene synthase (EC 4.2.3.95, Cop6) is an enzyme with systematic name (-)-alpha-cuprenene hydrolase (cyclizing, (-)-alpha-cuprenene-forming). This enzyme catalyses the following chemical reaction

(2E,6E)-farnesyl diphosphate ⇌ (-)-alpha-cuprenene + diphosphate

The enzyme from the fungus Coprinopsis cinerea produces (-)-alpha-cuprenene with high selectivity.