Syme (also Symes, Simes) is a surname, and may refer to:
Colin Syme (1903–1986), an Australian medical administrator and innovator
David Syme (1827–1908), a Scottish-Australian newspaper proprietor of The Age
David Syme (pianist) (born 1949), an American pianist.
Don Syme, an Australian computer scientist and creator of the F# programming language
Ebenezer Syme (1826–1860), a Scottish-Australian journalist, proprietor and manager of The Age
Geoffrey Syme (1873-1942), son of David Syme, who succeeded his father as proprietor and owner of The Age
George Adlington Syme (1859–1929), an Australian surgeon.
Hugh Syme (GC) (1903-1965), a naval officer and bomb disposal operative, and employee of The Age.
Hugh Syme, a Canadian musician and a Juno Award-winning graphic artist
James Syme (1799–1870), a pioneering Scottish surgeon.
Jennifer Syme (1972–2001), an American actress and production assistant.
John Syme (1795–1861), a Scottish portrait-painter
John Thomas Irvine Boswell Syme (1822–1888), a British botanist
Ronald Syme (1903–1989), a New Zealand-born historian of ancient Rome and classicist.
Fiction
Syme (1984), a minor character in George Orwell's Nineteen Eighty-Four
Gabriel Syme, a character in G.K. Chesterton's The Man Who Was Thursday