Industry Biotechnology Headquarters Newark Type of business Private | Website www.DNA20.com Founded 2003 | |
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Founders Sridhar Govindarajan, Claes Gustafsson, Jeremy Minshull, Jon Ness Products Gene Synthesis, Protein Engineering, Protein Production, Bioinformatics | ||
Dna2 0 protein expression engineering
DNA2.0 provides products and services for life science and Synthetic biology research. DNA2.0 also provides free access to research tools such as Gene Designer, DNA Atlas and a gRNA designer.
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Dna2 0 on tech closeup
The company
DNA2.0 was founded in 2003, in Menlo Park, California. The company is privately held and continues to have all research, development and production in California, currently in their 50,000 sq ft Newark facility. It began and continues as a gene synthesis and protein engineering provider to academia, government and the pharmaceutical, chemical, agricultural and biotechnology industries. Gene Synthesis rapidly replaced molecular cloning for many academic and corporate labs, as "foundries for the biotechnology age" allowing made-to-order genes for biological research. DNA2.0 was featured on the PBS show Nova ScienceNow to show how genes are created synthetically in a lab. In 2008, the company supplied some of the DNA stretches used to create a synthetic bacterial genome. Dan Rather Reports included DNA2.0 in their episode on Synthetic Biology and how it is solving "some of the most important problems facing the world." In 2009, The Scientist named the codon design algorithms (now trademarked as GeneGPS) developed by DNA2.0 as one of the Top 10 Innovations of the year for Life Sciences. DNA2.0 developed the Electra Vector System, a universal cloning system that utilizes the type IIS restriction enzyme SapI and T4 DNA ligase in a single-tube reaction. DNA2.0 has made some molecular components, such as synthetic fluorescent proteins, available in open-access collections of DNA parts (BioBricks Foundation). DNA2.0 is a founding member of the International Gene Synthesis Consortium (IGSC) to promote biosecurity in the gene-synthesis industry. There are over 1,200 published scientific articles using DNA2.0 products and/or services, of which 44 include company employees as an author(s).
Research Tools
Partnerships
Patents
US 9290552, Minshull & Theodorou, "Fluorescent and colored proteins and methods for using them", issued March 22, 2016
US 9206433, Minshull; Ness & Theodorou, "Methods, compositions and kits for a one-step DNA cloning system", issued December 8, 2015
US 9102944, Ness & Minshull, "Methods, compositions and kits for one-step DNA cloning using DNA topoisomerase", issued August 11, 2015
US 8975042, Minshull & Theodorou, "Fluorescent and colored proteins and methods for using them", issued March 10, 2015
US 8825411, Govindarajan; Minshull & Ness, "Design, synthesis and assembly of synthetic nucleic acids", issued September 2, 2014
US 8635029, Gustafsson; Govindarajan & Minshull, "Systems and methods for biopolymer engineering", issued January 21, 2014
US 8412461, Gustafsson; Govindarajan & Minshull, "Systems and methods for antibody engineering", issued April 2, 2013
US 8401798, Welch & Gustafsson, "Systems and methods for constructing frequency lookup tables for expression systems", issued March 19, 2013
US 8323930, Ness & Minshull, "Methods, compositions and kits for one-step DNA cloning using DNA topoisomerase", issued December 4, 2012
US 8158391, Gross; Lu & Ness et al., "Production of an .alpha.-carboxyl-.omega.-hydroxy fatty acid using a genetically modified Candida strain", issued September 28, 2010
US 8126653, Welch & Gustafsson, "Synthetic nucleic acids for expression of encoded proteins", issued February 28, 2012
US 8005620, Gustafsson; Govindarajan & Minshull, "Systems and methods for biopolymer engineering", issued August 23, 2011
US 7805252, Gustafsson; Govindarajan & Ness et al., "Systems and methods for designing and ordering polynucleotides", issued September 28, 2010
US 7561973, Welch & Gustafsson, "Methods for determining properties that affect an expression property value of polynucleotides in an expression system", issued July 14, 2009
US 7561972, Welch & Gustafsson, "Synthetic nucleic acids for expression of encoded proteins", issued July 14, 2009